Notable people from the Town of Whitby
- John Wilson Bengough, political cartoonist
- Kat Burns and Kyle Donnelly of the band Forest City Lovers
- Drake Caggiula, hockey player for the Edmonton Oilers
- Caroline Nichols Churchill, American feminist, author, and editor
- Sandy Cohen, hockey player
- Chuck Coles, singer/songwriter for the Organ Thieves, southern and soul-influenced experimental hard rock band
- Kurtis Conner, comedian
- A. J. Cook, actress
- Neil Crone, actor and writer for local newspaper, stars on kid’s television show Really Me
- Dave Devall, weather reporter for CFTO-TV
- Jim Flaherty, late member of the Canadian House of Commons and Minister of Finance
- Adam Foote, NHL player for Colorado Avalanche, Stanley Cup winner, Olympic Gold Medalist and former member of Team Canada
- Hamar Greenwood, Chief Secretary for Ireland 1920–1922
- Zack Greer, plays in the National Lacrosse League for the Denver Outlaws
- Jay Harrison, hockey player, currently an unrestricted free agent.
- Hello Beautiful, band
- May Irwin, businesswoman, pioneer film actress, singer and star of vaudeville, participant in first screen kiss in cinematic history in Thomas Edison‘s 1896 film The Kiss
- k-os, rapper, singer, songwriter and record producer
- John LaFontaine, member of the Saskatchewan Rush of the NLL
- Priscilla Lopes-Schliep, bronze medalist in the hurdles at the 2008 Olympics
- Andrew Martin, WWE wrestler, best known by his ring name, Test
- Leslie McFarlane, writer of the Hardy Boys novels
- Lori Melien, Olympic Bronze Medalist swimmer
- Aaron Milton (born 1992), Canadian football player
- Andrea Muizelaar, winner of Canada’s Next Top Model
- James Neal, NHL hockey player for the Nashville Predators
- Joe Nieuwendyk, NHL hockey player, Stanley Cup winner, Olympic Gold Medalist and former member of Team Canada, Hockey Hall of Fame Inductee (2011)
- Anne Ottenbrite, Olympic Gold Medalist swimmer
- Keith Primeau, former NHL player
- Wayne Primeau, former NHL player
- Protest The Hero, progressive metal band
- Gavin Prout, National Lacrosse League player with Colorado Mammoth
- Paul Ranger, NHL player for Tampa Bay Lightning and Toronto Maple Leafs
- Liam Reddox, hockey player
- Gary Roberts, former NHL player
- TJ Rogers, Professional Skateboarder
- Sid Ryan, President of the Ontario Federation of Labour
- O. J. Santiago, NFL football player
- Tyler Seguin, ice hockey player for the Dallas Stars
- J. Torres, comic book writer
- Kristina Vaculik, member of the London 2012 Canadian Olympic artistic gymnastics team, who helped Canada place fifth in the team finals
- Kelita Zupancic, Judoka and Olympian, member of the London 2012 Canadian Olympic Judo team also World Ranked No. 1 in 2013